INTERLEUKIN-2 PRODUCTION BY PRIMARY ADULT T-CELL LEUKEMIA TUMOR-CELLS IS MACROPHAGE DEPENDENT

被引：7

作者：

ARIMA, N ^{[1
]}

DAITOKU, Y ^{[1
]}

HIDAKA, S ^{[1
]}

YAMAMOTO, Y ^{[1
]}

FUJIMOTO, K ^{[1
]}

MATSUSHITA, K ^{[1
]}

OHTSUBO, H ^{[1
]}

FUKUMORI, J ^{[1
]}

TANAKA, H ^{[1
]}

ONOUE, K ^{[1
]}

机构：

[1] KUMAMOTO UNIV,INST MED IMMUNOL,DEPT BIOCHEM,KUMAMOTO 860,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1992年 / 41卷 / 04期

关键词：

ATL; CYTOKINES; IL-2; PRODUCTION;

D O I：

10.1002/ajh.2830410407

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated the cellular requirements for IL-2 production by autocrine proliferating tumor cells from four patients with adult T cell leukemia (ATL). Cultures of these ATL cells both produced endogenous IL-2 protein in the absence of added mitogen and proliferated at higher levels when exogenous recombinant IL-2 was added. Depletion of macrophages in the tumor cell cultures resulted in a sharp decline in tumor cell IL-2 production, while re-addition of macrophages reconstituted this response. Macrophage-derived factors including IL-6 and IL-1 also reconstituted IL-2 production in these macrophage depleted cultures. These results raise the possibility that macrophages may play a central role in HTLV-I mediated immortalization of T cells.

引用

页码：258 / 263

页数：6

共 28 条

[1]

ARIMA N, 1986, BLOOD, V68, P779

[2]

ARIMA N, 1987, J IMMUNOL, V138, P3039

[3]

DELARCO JE, 1978, P NATL ACAD SCI USA, V75, P4001

[4]

DOLITTLE RF, 1983, SCIENCE, V221, P275

[5] CLOSE SIMILARITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND V-ERB-B ONCOGENE PROTEIN SEQUENCES [J].

DOWNWARD, J ;

YARDEN, Y ;

MAYES, E ;

SCRACE, G ;

TOTTY, N ;

STOCKWELL, P ;

ULLRICH, A ;

SCHLESSINGER, J ;

WATERFIELD, MD .

NATURE, 1984, 307 (5951) :521-527

[6] AUTOCRINE GROWTH-STIMULATION OF A HUMAN T-CELL LYMPHOMA LINE BY INTERLEUKIN-2 [J].

DUPREZ, V ;

LENOIR, G ;

DAUTRYVARSAT, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :6932-6936

[7]

FARRAR JJ, 1980, J IMMUNOL, V125, P793

[8]

Fukui K, 1983, Mol Biol Med, V1, P447

[9] B-CELL-STIMULATORY FACTOR-II (BETA-2 INTERFERON) FUNCTIONS AS A 2ND SIGNAL FOR INTERLEUKIN-2 PRODUCTION BY MATURE MURINE T-CELLS [J].

GARMAN, RD ;

JACOBS, KA ;

CLARK, SC ;

RAULET, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7629-7633

[10] IMMORTALIZED LYMPHOCYTES-B PRODUCE B-CELL GROWTH-FACTOR [J].

GORDON, J ;

LEY, SC ;

MELAMED, MD ;

ENGLISH, LS ;

HUGHESJONES, NC .

NATURE, 1984, 310 (5973) :145-147

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