RAPID AND COMPLETE CHIRAL CHROMATOGRAPHIC-SEPARATION OF RACEMIC QUATERNARY TROPANE ALKALOIDS - COMPLEMENTARY USE OF A CELLULOSE-BASED CHIRAL STATIONARY PHASE IN REVERSED-PHASE AND NORMAL-PHASE MODES - A MECHANISTIC STUDY

Complete chromatographic separations of a wide range of different tropane alkaloid stereoisomers on a commercially available cellulose-based chiral stationary phase (CSP) are described. The separations were achieved by using cellulose tris(3,5-dimethylphenyl)carbamate as CSP with both an aqueous and an organic mobile phase with different ionic modifiers. The effects of totally different modifiers in both mobile phases on the chromatographic resolution are described.