CSF NEURON-SPECIFIC ENOLASE AFTER METHOHEXITAL ACTIVATION DURING ELECTROCORTICOGRAPHY

被引：35

作者：

RABINOWICZ, AL ^{[1
]}

CORREALE, JD ^{[1
]}

COULDWELL, WT ^{[1
]}

DEGIORGIO, CM ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH MED,DEPT NEUROSURG,CTR EPILEPSY,LOS ANGELES,CA 90033

来源：

NEUROLOGY | 1994年 / 44卷 / 06期

关键词：

D O I：

10.1212/WNL.44.6.1167

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report changes in CSF and serum neuron-specific enolase (NSE) before and after methohexital infusion during electrocorticography in three patients undergoing epilepsy surgery. NSE is a critical enzyme for energy metabolism that accounts for 1.5% of all soluble brain protein and is an accepted marker of neuronal injury. CSF NSE rose three-to fourfold from baseline within 60 minutes after methohexital activation. Serum NSE was unchanged. This report supports evidence that CSF NSE rises acutely after induction of epileptiform activity and suggests that CSF NSE is a marker of seizure activity.

引用

页码：1167 / 1169

页数：3

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