NON-ISLET-CELL TUMOR-ASSOCIATED WITH HYPOGLYCEMIA IN A CHILD - SUCCESSFUL LONG-TERM THERAPY WITH GROWTH-HORMONE

被引：15

作者：

AGUS, MSD

KATZ, LEL

SATINSMITH, M

MEADOWS, AT

HINTZ, RL

COHEN, P

机构：

[1] UNIV PENN, CHILDRENS HOSP PHILADELPHIA,SCH MED,DEPT PEDIAT, DIV ENDOCRINOL, PHILADELPHIA, PA 19104 USA

[2] HARVARD UNIV, CHILDRENS HOSP, SCH MED, DEPT PEDIAT, BOSTON, MA 02115 USA

[3] STANFORD UNIV, MED CTR, STANFORD, CA 94305 USA

来源：

JOURNAL OF PEDIATRICS | 1995年 / 127卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(95)70071-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Hypoglycemia occurred in a 2-year-old girl with neuroblastoma, Initially, growth hormone secretion was suppressed, and she had low levels of insulin-like growth factor (IGF)-I and IGF binding protein-3, but elevated levels of large molecular weight IGF-II, We postulated that the pathogenesis of her hypoglycemia involved production of IGF-II by her neuroblastoma, leading to GH suppression and an abnormally elevated ratio of IGF to IGF binding protein, She was successfully treated with growth hormone; treatment was associated with normalization of the growth hormone-dependent growth factor levels and with euglycemia.

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页码：403 / 407

页数：5

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