MAGNOLOL PROTECTS HUMAN SPERM MOTILITY AGAINST LIPID-PEROXIDATION - A SPERM HEAD FIXATION METHOD

被引：21

作者：

LIN, MH

CHAO, HT

HONG, CY

机构：

[1] NATL YANG MING UNIV,COLL MED,INST TRADIT MED,TAIPEI,TAIWAN

[2] VET GEN HOSP,DEPT MED,TAIPEI,TAIWAN

[3] VET GEN HOSP,DEPT OBSTET & GYNECOL,TAIPEI,TAIWAN

来源：

ARCHIVES OF ANDROLOGY | 1995年 / 34卷 / 03期

关键词：

LIPID PEROXIDATION; SPERM MOTILITY; CHINESE MEDICINAL HERB; MAGNOLOL;

D O I：

10.3109/01485019508987843

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

It was previously reported that magnolol, isolated from the Chinese medicinal herb Magnolia officinalis, had a potent inhibitory activity on lipid peroxidation. Since sperm motility could be suppressed by lipid peroxidation, this study examines the protective effect of magnolol on lipid peroxidation-suppressed sperm motility. FeSO4 was used to induced lipid peroxidation and sperm motility was expressed as tail beat frequency (TBF) measured with a sperm head fixation method. Magnolol at 10(-9) to 10(-7) M significantly reversed the FeSO4-suppressed TBF. Magnolol significantly inhibited the generation of malondialdehyde (MDA), the end product of lipid peroxidation, in sperm. Magnolol protected sperm motility by inhibiting lipid peroxidation in sperm.

引用

页码：151 / 156

页数：6

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