INHIBITION OF EPINEPHRINE-INDUCED VASOSPASM WITH ADRENOCEPTOR BLOCKADE IN THE RAT CREMASTER MUSCLE

被引：2

作者：

HARTSOCK, LA ^{[1
]}

SEABER, AV ^{[1
]}

URBANIAK, JR ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT SURG,ORTHOPAED RES LABS,POB 3093,DURHAM,NC 27710

来源：

MICROSURGERY | 1991年 / 12卷 / 01期

关键词：

D O I：

10.1002/micr.1920120111

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This study demonstrates that intravenous epinephrine causes arterial vasospasm, but not venous constriction, in the microcirculation of the rat cremaster muscle. This effect can be blocked by a smooth muscle relaxant such as papaverine or an alpha receptor antagonist such as phentolamine. Circulating vasospastic agents such as epinephrine are important determinants of microcirculatory blood flow, and inhibition by pharmacologic means may enhance blood flow and survival in microvascular surgery. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：55 / 59

页数：5

共 16 条

[1]

Seyfer AE, Seaber AV, Dombrose EA, Urbaniak JR, Coagulation changes in elective surgery and trauma, Ann Surg, 193, pp. 210-213, (1982)

[2]

Smith EL, Hill RL, Lehman IR, Lefkowitz RJ, Handler P, White A, Principles of Biochemistry: Mammalian Biochemistry, (1983)

[3]

Hjemdahl P, Belfrage E, Daleskog M, Vascular and metabolic effects of circulating epinephrine and norephinephrine, Clin Invest, 64, pp. 1221-1228, (1979)

[4]

Szwed JT, Friedman JJ, Comparative effects of norepinephrine, epinephrine, and angiotensin on pre and postcapillary resistance vessels in dog skeletal muscle, Microvasc Res, 9, pp. 206-221, (1975)

[5]

Youmans WB, The visceral nervous system and skeletal muscle activity, Am J Phys Med, 46, pp. 173-188, (1967)

[6]

Alpert JS, Coffman JD, Effects of IV epinephrine on skeletal muscle, skin, and subcutaneous blood flow, Am J Physiol, 216, pp. 156-160, (1969)

[7]

Strock PE, Majno G, Microvascular changes in acutely ischemic rat muscle, Surg Gynecol Obstet, 129, pp. 1213-1224, (1969)

[8]

Grant RT, Direct observation of skeletal muscle blood vessels (rat cremaster), J Physiol, 172, pp. 123-137, (1964)

[9]

Baez S, An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy, Microvas Res, 5, pp. 384-394, (1973)

[10]

Altura BM, Chemical and humoral regulation of blood flow through the precapillary sphincter, Microvasc Res, 3, pp. 361-384, (1971)

← 1 2 →