ENANTIOMERIC COMPOSITION OF TRANS-DIHYDRODIOLS FORMED FROM MESO-K-REGION ARENE OXIDES BY MICROSOMAL EPOXIDE HYDROLASE

被引：2

作者：

HABER, MT ^{[1
]}

NASHED, NT ^{[1
]}

JERINA, DM ^{[1
]}

机构：

[1] NIDDK,BIOORGAN CHEM LAB,BETHESDA,MD 20892

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

MESO-K-REGION ARENE OXIDES; BENZO[E]PYRENE; PYRENE; PHENANTHRENE; EPOXIDE HYDROLASE;

D O I：

10.1016/S0960-894X(00)80465-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Absolute configurations for the enantiomers of trans-4,5-dihydroxy-4,5-dihydrobenzo[e]pyrene were determined by the exciton chirality method and by correlation of physical properties of their (-)-(menthyloxy)acetyl diesters. Microsomal epoxide hydrolase catalyzed the hydrolysis of K-region arene oxides of benzo[e]pyrene, pyrene. and phenanthrene to trans-dihydrodiols containing 83 %, 86 %, and 42 % of the R,R enantiomer, respectively.

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页码：1729 / 1734

页数：6

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