INDUCTION OF GROUP-1 AND GROUP-2 UDP-GLUCURONOSYLTRANSFERASE IN MICROSOMES FROM THE LIVERS OF C57 BL-6 MICE

被引：19

作者：

BATT, AM ^{[1
]}

MARTIN, N ^{[1
]}

SIEST, G ^{[1
]}

机构：

[1] FAC SCI PHARMACEUT & BIOL NANCY, BIOCHIM PHARMACOL LAB, CNRS, ERA 698, F-54000 NANCY, FRANCE

来源：

TOXICOLOGY LETTERS | 1981年 / 9卷 / 04期

关键词：

D O I：

10.1016/0378-4274(81)90010-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In a study of multiple forms of liver microsomal UDP-glucuronosyltransferase (EC 2.4.1.17) with different substrate specificities, enzyme induction was examined in inducible C57 Bl/6 mice pretreated with phenobarbital, 3-methylcholanthrene, Aroclor 1254, safrole, .beta.-naphthoflavone and pregnenolone-16-.alpha.-carbonitrile. Phenobarbital and 3-methylcholanthrene were the most potent inducers. 3-Methylcholanthrene stimulated the glucuronidation of 4-nitrophenol, 4-bromophenol and 4-chlorophenol (group-1 substrates) more than phenobarbital; phenobarbital stimulated the glucuronidation of 4-hydroxyphenobarbital, menthol, eugenol, 4-hydroxybiphenyl, morphine, 1-borneol, 4-hydroxyphenytoin and 1,2,3,4-tetrahydro-1-naphthol (group-2 substrates). This pattern was analogous to that observed in rat liver microsomes.

引用

页码：355 / 360

页数：6

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