THE ROLE OF CAPSAICIN-SENSITIVE AFFERENT NERVES IN PROTECTIVE EFFECT OF CAPSAICIN AGAINST ABSOLUTE ETHANOL-INDUCED GASTRIC-LESIONS IN RATS

被引：41

作者：

UCHIDA, M

YANO, S

WATANABE, K

机构：

[1] Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 55卷 / 02期

关键词：

D O I：

10.1254/jjp.55.279

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of capsaicin-sensitive afferent nerves in gastroprotection by capsaicin was investigated in the absolute ethanol-induced gastric lesion model in rats. Capsaicin (0.1 and 0.5 mg/kg, p.o.) inhibited the lesion formation dose-dependently. The protective effect of capsaicin was attenuated by indomethacin-pretreatment and disappeared in capsaicin-sensitive nerve degenerated rats. Capsaicin did not induce the distension of gastric mucosal folds. These results suggested that stimulation of capsaicin-sensitive afferent nerves by capsaicin would enhance the prostaglandin formation, leading to an inhibition of gastric lesions.

引用

页码：279 / 282

页数：4

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