CARDIOVASCULAR EFFECTS OF ORG OD 14 - A NEW STEROIDAL THERAPY FOR CLIMACTERIC SYMPTOMS

被引：28

作者：

HARDIMAN, P

NIHOYANNOPOULOS, P

KICOVIC, P

GINSBURG, J

机构：

[1] ROYAL FREE HOSP, DEPT ENDOCRINOL, LONDON NW3 2QG, ENGLAND

[2] HAMMERSMITH HOSP, DEPT CLIN CARDIOL, LONDON W12 0NN, ENGLAND

[3] ORGANON INT BV, MED RES & DEV UNIT, OSS, NETHERLANDS

来源：

MATURITAS | 1991年 / 13卷 / 03期

关键词：

ORG OD 14; MENOPAUSE; BLOOD CIRCULATION; PLETHYSMOGRAPHY; CARDIAC OUTPUT;

D O I：

10.1016/0378-5122(91)90198-Y

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The cardiovascular effects of Org OD 14, a synthetic steroid which relieves climacteric symptoms without stimulating the endometrium, were assessed in a group of healthy post-menopausal women. Limb blood flow was measured by venous occlusion plethysmography. Resting forearm blood flow, the dilator response to anoxic exercise and heart rate increased significantly after six weeks of drug treatment. Hand flow was unchanged. The cardiovascular effects of Org OD 14 differ from those seen with oestrogens, in keeping with the unique pharmacological profile of this steroid.

引用

页码：235 / 242

页数：8

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