INOSITOL HEXAKISPHOSPHATE RECEPTOR IDENTIFIED AS THE CLATHRIN ASSEMBLY PROTEIN-AP-2

被引：119

作者：

VOGLMAIER, SM

KEEN, JH

MURPHY, JE

FERRIS, CD

PRESTWICH, GD

SNYDER, SH

THEIBERT, AB

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205

[3] UNIV ALABAMA,SCH MED,NEUROBIOL RES CTR,UAB STN,BIRMINGHAM,AL 35294

[4] THOMAS JEFFERSON UNIV,SCH MED,DEPT PHARMACOL,JEFFERSON CANC INST,PHILADELPHIA,PA 19107

[5] SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81473-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the α-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis. © 1992 Academic Press, Inc.

引用

页码：158 / 163

页数：6

共 20 条

[1] STRUCTURAL RELATIONSHIPS BETWEEN CLATHRIN ASSEMBLY PROTEINS FROM THE GOLGI AND THE PLASMA-MEMBRANE [J].