RETINAL INJURY INDUCED BY NEAR-ULTRAVIOLET RADIATION IN APHAKIC AND PSEUDOPHAKIC MONKEY EYES - A PRELIMINARY-REPORT

被引：26

作者：

LI, ZL

TSO, MOM

JAMPOL, LM

MILLER, SA

WAXLER, M

机构：

[1] Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois at Chicago College of Medicine

[2] Department of Ophthalmology, Northwestern University Medical School, Chicago

[3] Food and Drug Administration, Washington, DC

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1990年 / 10卷 / 04期

关键词：

APHAKIA; HISTOPATHOLOGY; NEAR-ULTRAVIOLET RADIATION; PSEUDOPHAKIA; RETINAL BURNS; RETINAL PIGMENT EPITHELIUM;

D O I：

10.1097/00006982-199010000-00014

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The effect of repeated exposures to low-intensity, near-ultraviolet (UV) radiation on the retinas of phakic, aphakic, and pseudophakic monkey eyes was studied. Ten eyes (4 aphakic eyes, 3 pseudophakic eyes, and 3 normal phakic eyes) of five rhesus monkeys were used. The near-UV radiation was generated by a high-pressure mercury vapor lamp with a total radiance of 14.43 mW/cm2/sr. Exposure regimens were 5 minutes a day for 10 days, 15 minutes a day for 5 days, or 60 minutes a day for 5 days. The retinas of aphakic and pseudophakic eyes were exposed to a daily dose of more than 0.97 J/cm2, or a total dose of more than 4.9 J/cm2 in 5 days at a retinal irradiance of more than 1.0 mW/cm2. Three of four aphakic eyes and one of three pseudophakic eyes showed clinical and pathologic retinal lesions after radiation. None of the three phakic eyes was damaged. The retinal lesions showed mild opalescent thickening ophthalmoscopically and retinal pigment epithelial staining by fluorescein angiography. Histopathologically, the retinal pigment epithelium was the site of primary injury by near-UV radiation.

引用

页码：301 / 314

页数：14

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