QUANTITATIVE MEASUREMENT OF MONOCLONAL-ANTIBODY DISTRIBUTION AND BLOOD-FLOW USING POSITRON EMISSION TOMOGRAPHY AND I-124 IN PATIENTS WITH BREAST-CANCER

被引：74

作者：

WILSON, CB

SNOOK, DE

DHOKIA, B

TAYLOR, CVJ

WATSON, IA

LAMMERTSMA, AA

LAMBRECHT, R

WAXMAN, J

JONES, T

EPENETOS, AA

机构：

[1] HAMMERSMITH HOSP, IMPERIAL CANC RES FUND, ONCOL GRP, LONDON W12 0HS, ENGLAND

[2] HAMMERSMITH HOSP, MRC, ONCOL UNIT, LONDON W12 0HS, ENGLAND

[3] KING FAISAL SPECIALIST HOSP & RES CTR, RIYADH 11211, SAUDI ARABIA

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 47卷 / 03期

关键词：

D O I：

10.1002/ijc.2910470305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The uptake and in vivo quantitation of monoclonal antibodies (MAbs) has been measured non-invasively using positron emission tomography (PET) and iodine-124 in 9 patients with breast ductal carcinoma. Blood-flow measurements were also made using oxygen-15-labelled water and PET to evaluate antibody delivery; 7 patients were studied with HMFG1 antibody and 2 patients with a non-specific antibody. Tumour uptake ranged from 2-7.7 x 10(-3%) of injected dose per gram of tissue. Values for normal tissue including liver, lung and bone were also obtained. In 2 out of 7 patients studied with the specific antibody, uptake was greater than that seen with the non-specific antibody. There was no correlation between antibody uptake and blood flow. This report exemplifies the potential of PET for the non-invasive and accurate quantitative assessment of targeted antibody which is a prerequisite to therapy.

引用

页码：344 / 347

页数：4

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