THE SYNTHESIS OF (4R-CIS)-1,1-DIMETHYLETHYL 6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE, A KEY INTERMEDIATE FOR THE PREPARATION OF CI-981, A HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE

被引：77

作者：

BROWER, PL

BUTLER, DE

DEERING, CF

LE, TV

MILLAR, A

NANNINGA, TN

ROTH, BD

机构：

[1] WARNER LAMBERT PARKE DAVIS,DIV PARKE DAVIS PHARMACEUT RES,DEPT CHEM DEV,HOLLAND,MI 49424

[2] CHEM DEPT,ANN ARBOR,MI 48105

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)74189-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three alternative methods for the synthesis of the optically active heptanoate (6), a key intermediate in the preparation of a highly potent and tissue selective HMG Co-A reductase inhibitor are described.

引用

页码：2279 / 2282

页数：4

共 34 条

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