ESCHERICHIA-COLI GENES INVOLVED IN CELL-SURVIVAL DURING DORMANCY - ROLE OF OXIDATIVE STRESS

被引：39

作者：

EISENSTARK, A ^{[1
]}

MILLER, C ^{[1
]}

JONES, J ^{[1
]}

LEVEN, S ^{[1
]}

机构：

[1] UNIV MISSOURI, DIV BIOL SCI, COLUMBIA, MO 65211 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91338-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When Escherichia coli cells reach stationary phase of growth, specific gene products are synthesized that protect cells while dormant. "Aged" cells may remain viable in cultures for years. For example, agar cultures stored for 38 years still had more than 105 viable cells/ml. However, when specific mutants were cultured, the population of these mutants dropped sharply after 4-10 days. This defect is termed "Stationary-Phase-Death." Each mutant strain was hypersensitive to near-ultraviolet radiation and other oxidative agents. Bovine catalase rescued many of the mutants from death in dormancy, suggesting that specific gene products protect "aged" cells against oxidative damage. © 1992.

引用

页码：1054 / 1059

页数：6

共 25 条

[1] RESTORATION OF ESCHERICHIA-COLI STRAIN-B AFTER IRRADIATION - ITS DEPENDENCE ON SUBOPTIMAL GROWTH CONDITIONS [J].