SYNTHESIS OF 1-O-ACYLGLYCEROL 2,3-CYCLIC PHOSPHATE - DETERMINATION OF THE ABSOLUTE STRUCTURE OF PHYLPA, A SPECIFIC INHIBITOR OF DNA-POLYMERASE ALPHA

被引：47

作者：

KOBAYASHI, S

TOKUNOH, R

SHIBASAKI, M

SHINAGAWA, R

MURAKAMIMUROFUSHI, K

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

[2] OCHANOMIZU UNIV,FAC SCI,BUNKYO KU,TOKYO 112,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 25期

关键词：

PHYLPA; DNA POLYMERASE-ALPHA; LYSOPHOSPHATIDIC ACID; CYCLIC PHOSPHATE; CYCLOPROPANE; TRIS(TRIAZOLE) PHOSPHATE;

D O I：

10.1016/S0040-4039(00)60612-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four possible stereoisomers of PHYLPA, a specific inhibitor of DNA polymerase alpha, were synthesized in enantioselective manners. These isomers were examined for inhibition activity for DNA polymerase alpha, and the structure of PHYLPA was established as sodium 1-O-[(9'S, 10'R)-9',10'-methanohexadecanoyl]-sn-glycerol 2,3-cyclic phosphate.

引用

页码：4047 / 4050

页数：4

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