CHIRAL ORGANOMETALLIC REAGENTS .11. STEREOSELECTIVE EXCHANGE OF DIASTEREOTOPIC IODINE ATOMS BY MAGNESIUM IN 3-ALKOXY-1,1-DIIODOALKANES

被引：18

作者：

HOFFMANN, RW

KUSCHE, A

机构：

[1] Fachbereich Chemie, Universität Marburg, Marburg

来源：

CHEMISCHE BERICHTE | 1994年 / 127卷 / 07期

关键词：

1-IODOALKYLMAGNESIUM REAGENTS; STABILITY; CONFIGURATIONAL;

D O I：

10.1002/cber.19941270721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alpha-Iodoalkylmagnesium species were generated by reaction of 3-oxygenated 1,1-diiodoalkanes with isopropylmagnesium halides at -78-degrees-C. The resulting magnesium carbenoids were found to be configurationally stable at temperatures up to -20-degrees-C and were trapped by benzaldehyde or allyl iodide at low temperatures. Stereoselectivity on exchange of the diastereotopic iodine atoms in 3 was found to be low.

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页码：1311 / 1316

页数：6

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