INTERFERON THERAPY FOR PATIENTS MORE THAN 60 YEARS OF AGE WITH CHRONIC HEPATITIS-C

被引:33
作者
HORIIKE, N
MASUMOTO, T
NAKANISHI, K
MICHITAKA, K
KUROSE, K
OHKURA, I
ONJI, M
机构
[1] Third Department of Internal Medicine, Ehime University School of Medicine, Ehime
关键词
AGE; CHRONIC HEPATITIS; HEPATITIS C VIRUS; INTERFERON;
D O I
10.1111/j.1440-1746.1995.tb01088.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Nineteen patients aged > 60 years with chronic hepatitis C (CHC) received interferon (IFN) therapy and a complete response (CR) was achieved by five of them (26%). The incidence of CH with severe fibrosis in this elderly group was significantly higher than in another 52 patients with CHC who were < 60 years of age (the younger group; P < 0.05). There was no significant difference in the hepatitis C virus (HCV) genotype distribution between the elderly group and the younger group. However, the HCV-RNA titre was significantly higher in the elderly group than in the younger group (P < 0.05). There was no significant difference in the efficacy rate of IFN in the elderly and younger groups after standardization of the background factors. In the elderly group, the HCV-RNA titre was significantly lower in the patients achieving CR than in those with no response (P<0.05). These data suggest that elderly patients with a low HCV-RNA titre can still respond well to IFN therapy.
引用
收藏
页码:246 / 249
页数:4
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