CONCENTRATIONS OF ORAL LOMEFLOXACIN IN SERUM AND BRONCHIAL-MUCOSA

被引：18

作者：

BALDWIN, DR ^{[1
]}

HONEYBOURNE, D ^{[1
]}

ANDREWS, JM ^{[1
]}

ASHBY, JP ^{[1
]}

WISE, R ^{[1
]}

机构：

[1] DUDLEY RD GEN HOSP,DEPT MED MICROBIOL,BIRMINGHAM B18 7QH,W MIDLANDS,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 06期

关键词：

D O I：

10.1128/AAC.34.6.1017

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bronchial mucosal concentrations of lomefloxacin were determined for specimens obtained by fiber-optic bronchoscopy and compared with simultaneous concentrations in serum. The 23 patients studied were given anoral dose of 400 mg once daily for 4 days to achieve steady-state levels. The median concentration in serum was 2.5 μg/ml (range, 1.0 to 5 μg/ml), and the median bronchial mucosal concentration was 5.0 μg/g (range, 0.7 to 18.6 μg/g). The median percent penetration was 177% (range, 69 to 541%). The concentrations in serum and mucosa exceeded the MIC for 90% of strains of organisms causing bronchial infections but not sufficiently to recommend lomefloxacin for the routine treatment of pneumococcal infections.

引用

页码：1017 / 1019

页数：3

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