DETECTION OF POLYMORPHIC EPITHELIAL MUCINS IN THE SERUM OF SYSTEMIC BREAST-CANCER PATIENTS USING THE MONOCLONAL-ANTIBODY, NCRC-11

被引:21
作者
PRICE, MR [1 ]
CLARKE, AJ [1 ]
ROBERTSON, JFR [1 ]
OSULLIVAN, C [1 ]
BALDWIN, RW [1 ]
BLAMEY, RW [1 ]
机构
[1] CITY HOSP NOTTINGHAM,PROFESSORIAL SURG UNIT,NOTTINGHAM NG5 1PB,ENGLAND
关键词
D O I
10.1007/BF01740933
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Serum from patients with systemic breast cancer was found to contain elevated levels of polymorphic epithelial mucin (PEM) as detected using an immunoradiometric assay employing the monoclonal antibody NCRC-11. PEM was partially purified from pooled sera from these patients and the complex, polymorphic, high-molecular-mass (>400 kDa) mucin was identified by sodium dodecylsulphate/polyacrylamide gel electrophoresis, Western blotting and immunostaining with the NCRC-11 antibody. Serial serum samples from 16 patients with metastatic breast cancer were assayed for circulating PEM defined by the monoclonal antibody NCRC-11. The clinical course of disease in these patients was assessed independently as progressive, static or responsive. Increasing NCRC-11 antigen levels correlated with disease progression in 6/7 patients, and decreasing antigen levels correlated with an objective response to treatment in 5/6 patients. Measurement of NCRC-11-defined PEM antigen in patients undergoing therapy for metastatic breast cancer showed an overall accuracy of 75%. © 1990 Springer-Verlag.
引用
收藏
页码:269 / 272
页数:4
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