AUTOMATED SAMPLE PREPARATION AND CHROMATOGRAPHIC ANALYSIS - DETERMINATION OF CGS-10787B AND RELATED-COMPOUNDS

被引：11

作者：

LUDERS, RC

BRUNNER, LA

机构：

[1] Ciba-Geigy Corp, Ardsley, NY, USA, Ciba-Geigy Corp, Ardsley, NY, USA

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1987年 / 25卷 / 05期

关键词：

BIOLOGICAL MATERIALS - Chromatographic Analysis - CHEMICAL ANALYSIS - Sampling - CHEMICAL LABORATORIES - Automation - ROBOTS; INDUSTRIAL; -; Applications;

D O I：

10.1093/chromsci/25.5.192

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An automated method is described for analyzing biological samples originating from CGS 10787B drug disposition studies. The method incorporates a laboratory robot to prepare plasma and urine samples and a high performance liquid chromatographic system to simultaneously analyze for CGS 10787B, as well as metabolites and drug-related compounds. The robot aliquots the biological sample, adds an internal standard, and performs all the steps necessary for the liquid-liquid extraction and concentration of the drug and related components, while operating unattended around the clock.

引用

页码：192 / 197

页数：6