EFFECT OF SOME CENTRALLY ADMINISTERED PUTATIVE AMINO-ACID NEUROTRANSMITTERS ON CARRAGEENAN-INDUCED PAW EDEMA IN RATS

被引：17

作者：

BHATTACHARYA, SK ^{[1
]}

SARKAR, MK ^{[1
]}

机构：

[1] BANARAS HINDU UNIV, INST MED SCI, DEPT PHARMACOL, NEUROPHARMACOL LAB, VARANASI 221005, UTTAR PRADESH, INDIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1986年 / 38卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1986.tb04531.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The possible modulatory effect of central amino acid neurotransmitters on carrageenan-induced paw inflammation has been investigated in rats. Eight putative amino acid neurotransmitters were administered intracerebroventricularly and their effect on the peripheral inflammation was noted. The inhibitory amino acid transmitters, GABA, glycine and taurine attenuated the peripheral oedema, while the excitatory amino acid transmitters, glutamic acid and aspartic acid has a pro-inflammatory effect. However, the other putative amino acid neurotransmitters, proline and alanine (inhibitory) and cysteic acid (excitatory) did not affect carrageenan-induced oedema.

引用

页码：144 / 146

页数：3

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