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A MACROCIRCULAR ELLAGITANNIN, OENOTHEIN-B, SUPPRESSES MOUSE MAMMARY-TUMOR GENE-EXPRESSION VIA INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE

被引：40
作者：
AOKI, K
MARUTA, H
UCHIUMI, F
HATANO, T
YOSHIDA, T
TANUMA, S
机构：
[1] OKAYAMA UNIV,FAC PHARMACEUT SCI,OKAYAMA 700,JAPAN
[2] SCI UNIV TOKYO,BIOSCI RES INST,NODA,CHIBA 278,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 210卷 / 02期
关键词：
D O I：
10.1006/bbrc.1995.1665
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription. (C) 1995 Academic Press, Inc.
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页码：329 / 337
页数：9
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