SUSCEPTIBILITIES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENZYME AND VIRAL VARIANTS EXPRESSING MULTIPLE RESISTANCE-ENGENDERING AMINO-ACID SUBSTITUTIONS TO REVERSE-TRANSCRIPTASE INHIBITORS

被引：61

作者：

BYRNES, VW

EMINI, EA

SCHLEIF, WA

CONDRA, JH

SCHNEIDER, CL

LONG, WJ

WOLFGANG, JA

GRAHAM, DJ

GOTLIB, L

SCHLABACH, AJ

WOLANSKI, BS

BLAHY, OM

QUINTERO, JC

RHODES, A

ROTH, E

TITUS, DL

SARDANA, VV

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 06期

关键词：

D O I：

10.1128/AAC.38.6.1404

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To evaluate the potential that multiply resistant human immunodeficiency virus type 1 variants may arise during combination nucleoside and nonnucleoside reverse transcriptase inhibitor therapy, we constructed a series of mutant reverse transcriptase enzymes and viruses that coexpressed various combinations of resistance-associated amino acid substitutions. Substitutions at residues 100 (Leu-->Ile) and 181 (Tyr-->Cys), which mediate resistance to the nonnucleosides, suppressed resistance to 3'-azido-3'-deoxythymidine (AZT) when coexpressed with AZT-specific substitutions. However, a number of viral variants that exhibited significantly reduced susceptibilities to both classes of inhibitors were constructed.

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页码：1404 / 1407

页数：4

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