STRUCTURE AND SUPEROXIDE-DISMUTASE ACTIVITY OF RU(II), CU(II), AND MN(II) MACROCYCLIC COMPLEXES

被引：51

作者：

BIENVENUE, E

CHOUA, S

LOBORECIO, MA

MARZIN, C

PACHECO, P

SETA, P

TARRAGO, G

机构：

[1] UNIV MONTPELLIER 2,LMPM,EQUIPE CHIM SUPRAMOLEC,F-34095 MONTPELLIER 5,FRANCE

[2] CNRS,LMPM,F-34033 MONTPELLIER 1,FRANCE

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1995年 / 57卷 / 03期

关键词：

D O I：

10.1016/0162-0134(94)00020-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ru(II), Cu(II), and Mn(II) complexes of an unsymmetrical macrocycle Me containing pyrazole and amine nitrogen atoms as donor sites have been synthesized and studied in the solid state and in solution. Whereas Cu(II) and Mn(II) metals are complexed inside the macrocyclic cavity, the reaction of Me with Ru(DMSO)(4)Cl-2 leads to a complex Ru(Mc)(DMSO)(2)Cl-2 in which only the two sp(3) nitrogen donors are coordinated to the metal. In spite of these different structures, the three complexes compete with nitroblue tetrazolium toward the superoxide anion: the corresponding SOD-like activities are not very high but have the essential advantage of being totally [Ru(II) and Mn(II) complexes] or partially [Cu(II) complex] retained in the presence of water soluble proteins.

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页码：157 / 168

页数：12

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