INTERLEUKIN-10 IS A POTENT GROWTH AND DIFFERENTIATION FACTOR FOR ACTIVATED HUMAN LYMPHOCYTES-B

被引：1170

作者：

ROUSSET, F ^{[1
]}

GARCIA, E ^{[1
]}

DEFRANCE, T ^{[1
]}

PERONNE, C ^{[1
]}

VEZZIO, N ^{[1
]}

HSU, DH ^{[1
]}

KASTELEIN, R ^{[1
]}

MOORE, KW ^{[1
]}

BANCHEREAU, J ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, RES INST, PALO ALTO, CA 94304 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 05期

关键词：

B-CELL PROLIFERATION; IMMUNOGLOBULIN PRODUCTION;

D O I：

10.1073/pnas.89.5.1890

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin 10 (IL-10), originally identified as a T(H)2 helper T-cell product able to inhibit cytokine production by T(H)1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome. Here, we show that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen. IL-4 and IL-10 display additive effects and induce a strong increase in the number of viable cells. Moreover, IL-10 induces activated B cells to secrete large amounts of IgG, IgA, and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes. Thus, IL-10 may play an important role in the amplification of humoral responses.

引用

页码：1890 / 1893

页数：4

共 26 条

[1] LONG-TERM HUMAN B-CELL LINES DEPENDENT ON INTERLEUKIN-4 AND ANTIBODY TO CD40 [J].

BANCHEREAU, J ;

DEPAOLI, P ;

VALLE, A ;

GARCIA, E ;

ROUSSET, F .

SCIENCE, 1991, 251 (4989) :70-72

[2]

CHER DJ, 1987, J IMMUNOL, V138, P3688

[3] REGULATION OF HUMAN IGE SYNTHESIS .1. HUMAN IGE SYNTHESIS INVITRO IS DETERMINED BY THE RECIPROCAL ANTAGONISTIC EFFECTS OF INTERLEUKIN-4 AND INTERFERON-GAMMA [J].

CHRETIEN, I ;

PENE, J ;

BRIERE, F ;

MALEFIJT, RD ;

ROUSSET, F ;

DEVRIES, JE .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (02) :243-251

[4] DETECTION OF HUMAN CYTOKINE-SECRETING CELLS IN DISTINCT ANATOMICAL COMPARTMENTS [J].

CZERKINSKY, C ;

ANDERSSON, G ;

FERRUA, B ;

NORDSTROM, I ;

QUIDING, M ;

ERIKSSON, K ;

LARSSON, L ;

HELLSTRAND, K ;

EKRE, HP .

IMMUNOLOGICAL REVIEWS, 1991, 119 :5-22

[5] INTERLEUKIN-4 INHIBITS THE PROLIFERATION BUT NOT THE DIFFERENTIATION OF ACTIVATED HUMAN B-CELLS IN RESPONSE TO INTERLEUKIN-2 [J].

DEFRANCE, T ;

VANBERVLIET, B ;

AUBRY, JP ;

BANCHEREAU, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (04) :1321-1337

[6]

DEFRANCE T, 1987, J IMMUNOL, V139, P1135

[7] LYMPHOKINE-MEDIATED REGULATION OF THE PROLIFERATIVE RESPONSE OF CLONES OF T-HELPER-1 AND T-HELPER-2 CELLS [J].

FERNANDEZBOTRAN, R ;

SANDERS, VM ;

MOSMANN, TR ;

VITETTA, ES .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (02) :543-558

[8] 2 TYPES OF MOUSE T-HELPER CELL .4. TH2 CLONES SECRETE A FACTOR THAT INHIBITS CYTOKINE PRODUCTION BY TH1 CLONES [J].

FIORENTINO, DF ;

BOND, MW ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :2081-2095

[9] INTERLEUKIN-10, A NOVEL B-CELL STIMULATORY FACTOR - UNRESPONSIVENESS OF X-CHROMOSOME LINKED IMMUNODEFICIENCY-B CELLS [J].

GO, NF ;

CASTLE, BE ;

BARRETT, R ;

KASTELEIN, R ;

DANG, W ;

MOSMANN, TR ;

MOORE, KW ;

HOWARD, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) :1625-1631

[10] EXPRESSION OF INTERLEUKIN-10 ACTIVITY BY EPSTEIN-BARR-VIRUS PROTEIN BCRF1 [J].

HSU, DH ;

MALEFYT, RD ;

FIORENTINO, DF ;

DANG, MN ;

VIEIRA, P ;

DEVRIES, J ;

SPITS, H ;

MOSMANN, TR ;

MOORE, KW .

SCIENCE, 1990, 250 (4982) :830-832

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