SYNTHESIS OF AN ALPHA-(AMINOOXY)ARYLACETIC ESTER BY THE REACTION OF AN ALPHA-DIAZO ESTER WITH N-HYDROXYPHTHALIMIDE

被引：7

作者：

ACE, KW ^{[1
]}

HUSSAIN, N ^{[1
]}

LATHBURY, DC ^{[1
]}

MORGAN, DO ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,TONBRIDGE TN11 9AN,KENT,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 44期

关键词：

D O I：

10.1016/0040-4039(95)01697-G

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The a-diazo esters (6) and (7) react, in the absence of any catalyst, with a variety of HONR(2) and HON=CR(2) compounds to give the O-alkylated adducts (8) to (16). In particular, reaction of (7) with N-hydroxyphthalimide in refluxing benzene followed by deprotection gives the title compound (1).

引用

页码：8141 / 8144

页数：4

共 11 条

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[2]

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[4] RHODIUM-CARBENOID MEDIATED O-H INSERTION REACTIONS - O-H INSERTION VS H-ABSTRACTION AND EFFECT OF CATALYST [J].

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MILLER, DJ ;

MOODY, CJ ;

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[5]

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[6]

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[7]

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[8]

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[9]

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[10]

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