SYNTHESIS OF 3-DEAZANEPLANOCIN-A, A POWERFUL INHIBITOR OF S-ADENOSYLHOMOCYSTEINE HYDROLASE WITH POTENT AND SELECTIVE INVITRO AND INVIVO ANTIVIRAL ACTIVITIES

被引:112
作者
TSENG, CKH
MARQUEZ, VE
FULLER, RW
GOLDSTEIN, BM
HAINES, DR
MCPHERSON, H
PARSONS, JL
SHANNON, WM
ARNETT, G
HOLLINGSHEAD, M
DRISCOLL, JS
机构
[1] NCI,DIV CANC TREATMENT,DTP,MED CHEM LAB,BETHESDA,MD 20892
[2] UNIV ROCHESTER,MED CTR,DEPT BIOPHYS,ROCHESTER,NY 14642
[3] WELLESLEY COLL,DEPT CHEM,WELLESLEY,MA 02181
[4] STARKS ASSOCIATES INC,BUFFALO,NY 14213
[5] SO RES INST,BIRMINGHAM,AL 35255
关键词
D O I
10.1021/jm00127a007
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1442 / 1446
页数:5
相关论文
共 45 条
  • [1] AKSAMIT RR, 1982, J BIOL CHEM, V257, P621
  • [2] [Anonymous], 1974, INT TABLES XRAY CRYS, VIV, p[99, 149]
  • [3] 3-DEAZAADENOSINE, AN INHIBITOR OF ADENOSYLHOMOCYSTEINE HYDROLASE, INHIBITS REPRODUCTION OF ROUS-SARCOMA VIRUS AND TRANSFORMATION OF CHICK-EMBRYO CELLS
    BADER, JP
    BROWN, NR
    CHIANG, PK
    CANTONI, GL
    [J]. VIROLOGY, 1978, 89 (02) : 494 - 505
  • [4] BENNETT LL, 1968, MOL PHARMACOL, V4, P208
  • [5] BODNER AJ, 1981, BIOCHEM BIOPH RES CO, V98, P476, DOI 10.1016/0006-291X(81)90864-0
  • [6] Borchardt R. T., 1986, BIOL METHYLATION DRU, P227
  • [7] S-ADENOSYL-L-METHIONINE-DEPENDENT MACROMOLECULE METHYLTRANSFERASES - POTENTIAL TARGETS FOR THE DESIGN OF CHEMOTHERAPEUTIC-AGENTS
    BORCHARDT, RT
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (04) : 347 - 357
  • [8] BORCHARDT RT, 1984, J BIOL CHEM, V259, P4353
  • [9] Borchardt RT, 1977, BIOCH ADENOSYLMETHIO, P151
  • [10] BORCHARDT RT, 1986, BIOL METHYLATION DRU, P385