NO EVIDENCE FOR GENETIC-LINKAGE OF GILLES-DE-LA-TOURETTE SYNDROME ON CHROMOSOME-7 AND CHROMOSOME-18

被引：31

作者：

HEUTINK, P

VANDEWETERING, BJM

BREEDVELD, GJ

WEBER, J

SANDKUYL, LA

DEVOR, EJ

HEIBERG, A

NIERMEIJER, MF

OOSTRA, BA

机构：

[1] ERASMUS UNIV,HOSP DIJKZIGT,DEPT PSYCHIAT,ROTTERDAM,NETHERLANDS

[2] MARSHFIELD CLIN FDN MED RES & EDUC,MARSHFIELD,WI 54449

[3] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,ST LOUIS,MO 63110

[4] FRAMBU HELSESENTER,OSLO,NORWAY

[5] ERASMUS UNIV,DEPT CELL BIOL,3000 DR ROTTERDAM,NETHERLANDS

来源：

JOURNAL OF MEDICAL GENETICS | 1990年 / 27卷 / 07期

关键词：

D O I：

10.1136/jmg.27.7.433

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gilles de la Tourette syndrome is a heritable neuropsychiatric disorder. In order to determine the chromosomal localisation of the locus involved, genetic linkage studies were initiated in six extended families. The Gilles de la Tourette gene has been tentatively assigned to chromosome 18q22.1. In our present study no evidence for genetic linkage on chromosome 18 and chromosome 7 was obtained. Data from the markers tested made it possible to exclude the whole of chromosome 18 and the chromosome 7q21.3-qter region as a site for the Gilles de la Tourette gene.

引用

页码：433 / 436

页数：4

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