WEIGHT-GAIN AND WITHDRAWAL SYMPTOMS AFTER SMOKING CESSATION - A PREVENTIVE INTERVENTION USING D-FENFLURAMINE

被引：72

作者：

SPRING, B ^{[1
]}

WURTMAN, J ^{[1
]}

GLEASON, R ^{[1
]}

WURTMAN, R ^{[1
]}

KESSLER, K ^{[1
]}

机构：

[1] MIT,CAMBRIDGE,MA 02139

来源：

HEALTH PSYCHOLOGY | 1991年 / 10卷 / 03期

关键词：

CIGARETTE SMOKING; SMOKING CESSATION; WEIGHT; CARBOHYDRATES; FOOD INTAKE;

D O I：

10.1037/0278-6133.10.3.216

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Directly measured food intake in 31 overweight female smokers to test whether (a) calorie and carbohydrate intakes increase after smoking cessation and (b) double-blind d-fenfluramine (30 mg), a serotonin-releasing drug, suppresses weight gain, overeating, and dysphoric mood associated with stopping smoking. Placebo-treated patients grew dysphoric after smoking withdrawal and ate 300 kcal/day more from 2 to 28 days after, showing a 3.5-lb weight gain. Fat and protein intakes did not change, but carbohydrate intake increased (30% to 40%). D-fenfluramine prevented postcessation dysphoria. Although drug-treated patients ate more carbohydrate snacks just after quitting, they returned to baseline by 4 weeks, showing a 1.8-lb weight loss. Agents that enhance brain serotonin-mediated neurotransmission may help prevent weight gain, overeating, and dysphoric mood after smoking withdrawal.

引用

页码：216 / 223

页数：8

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