CISPLATIN-INDUCED EMESIS IN SUNCUS-MURINUS

被引：42

作者：

MUTOH, M

IMANISHI, H

TORII, Y

TAMURA, M

SAITO, H

MATSUKI, N

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TOKYO 113,JAPAN

[2] TORAY INDUSTRIES LTD,BASIC RES LABS,KANAGAWA 248,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 58卷 / 03期

关键词：

D O I：

10.1254/jjp.58.321

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Emetic responses to cisplatin and participation of vagal innervation in emesis were studied in suncus. Intraperitoneal and intravenous administration of cisplatin caused dose-dependent emesis. ED50 values, latencies and frequencies were not significantly different between the two administrations. Cis-diaqodiammineplatinum (DAP), an active metabolite of cisplatin, also induced emesis, but with significantly shorter latency. Vagotomy completely abolished both types of vomiting. These results suggest that cisplatin is metabolized to DAP that subsequently causes emesis through stimulation of the vagus afferent.

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页码：321 / 324

页数：4

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