BIOLOGICAL-ACTIVITIES OF CATFISH GLUCAGON AND GLUCAGONLIKE PEPTIDE

被引：15

作者：

HOOSEIN, NM

MAHRENHOLZ, AM

ANDREWS, PC

GURD, RS

机构：

[1] INDIANA UNIV, MED SCI PROGRAM, BLOOMINGTON, IN 47405 USA

[2] INDIANA UNIV, DEPT CHEM, BLOOMINGTON, IN 47405 USA

[3] PURDUE UNIV, DEPT BIOCHEM, W LAFAYETTE, IN 47907 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 143卷 / 01期

关键词：

D O I：

10.1016/0006-291X(87)90633-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of catfish glucagon and glucagon-like peptide to bind and activate mammalian glucagon receptors was investigated. Neither catfish peptide binds to glucagon receptors of rat liver, hypothalamus or pituitary. Neither stimulates adenylate cyclase activity in liver membranes. Catfish glucagon fails to activate adenylate cyclase in hypothalamic or pituitary membranes in contrast to mammalian glucagon. However, catfish glucagon-like peptide does stimulate hypothalamic and pituitary adenylate cyclase (EC50 .apprx. 1 pM) possibly through mammalian glucagon-like peptide receptors.

引用

页码：87 / 92

页数：6

共 27 条

[1]

ANDREWS PC, 1986, J BIOL CHEM, V261, P8128

[2]

ANDREWS PC, 1985, J BIOL CHEM, V260, P3910

[3] HAMSTER PREPROGLUCAGON CONTAINS THE SEQUENCE OF GLUCAGON AND 2 RELATED PEPTIDES [J].