HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ANTIGENEMIA IS ENHANCED IN PATIENTS WITH DISSEMINATED CYTOMEGALOVIRUS-INFECTION AND DEFICIENT LYMPHOCYTES-T

被引：7

作者：

FIALA, M

CONE, LA

CHRISTOPHER, R

KERMANI, V

GORNBEIN, JA

机构：

[1] IMMUNOBIOGENE INC,LOS ANGELES,CA 90025

[2] NATL ASSESSMENT CORP,PALM SPRINGS,CA 92262

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOMATH,LOS ANGELES,CA 90024

来源：

RESEARCH IN IMMUNOLOGY | 1991年 / 142卷 / 09期

关键词：

AIDS; RETINITIS; CMV; HIV-1; LYMPHOCYTE-T; ANTIGENEMIA; CD4 AND CD8 DEFICIENCIES; VIREMIA; P24; ANTIGEN;

D O I：

10.1016/0923-2494(91)90126-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have studied 61 patients with the acquired immunodeficiency syndrome (AIDS) regarding the relationships between disseminated cytomegalovirus (CMV) infection with CMV retinitis, HIV1 antigenaemia and CD4+ and CD8+ T-cell deficiency. HIV1 p24 antigenaemia was present in all patients with CMV retinitis (at a high concentration), but in only 28% of patients without retinitis (at a low concentration). Compared to patients without retinitis, those patients who developed retinitis had lower CD4+ and CD8+ prior to and during AIDS. CMV may contribute to deficiencies of T lymphocytes in patients with AIDS.

引用

页码：815 / 819

页数：5

共 20 条

[1] CYTOMEGALOVIRUS ACTIVATES TRANSCRIPTION DIRECTED BY THE LONG TERMINAL REPEAT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].