THE EFFECT OF ANTIADHESION MOLECULE ANTIBODY ON THE DEVELOPMENT OF COLLAGEN-INDUCED ARTHRITIS

被引：84

作者：

KAKIMOTO, K

NAKAMURA, T

ISHII, K

TAKASHI, T

IIGOU, H

YAGITA, H

OKUMURA, K

ONOUE, K

机构：

[1] DAIICHI PHARMACEUT CO LTD,TOKYO RES & DEV CTR,TOKYO,JAPAN

[2] NAGASAKI UNIV,SCH DENT,DEPT RADIOL,NAGASAKI 852,JAPAN

[3] JUNTENDO UNIV,SCH MED,DEPT IMMUNOL,TOKYO 113,JAPAN

来源：

CELLULAR IMMUNOLOGY | 1992年 / 142卷 / 02期

关键词：

D O I：

10.1016/0008-8749(92)90294-Y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In order to study how inflammatory cells including autoimmune lymphocytes interact with each other to develop collagen-induced arthritis (CIA), we injected monoclonal antibodies against mouse LFA-1 and ICAM-1 into DBA/1 mice immunized with type II collagen (CII). Both antibodies suppressed the development of CIA. These antibodies showed no effect on anti-CII antibody response, although they both significantly suppressed DTH response. It was suggested that antiadhesion molecule antibodies suppress CIA mainly through their effect on cell-mediated immunity, without affecting humoral immunity under the conditions used. © 1992.

引用

页码：326 / 337

页数：12

共 31 条

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