BLOCKADE OF THALAMIC GABA(B) RECEPTORS DECREASES EEG SYNCHRONIZATION

被引：35

作者：

JUHASZ, G

EMRI, Z

KEKESI, KA

SALFAY, O

CRUNELLI, V

机构：

[1] UNIV WALES COLL CARDIFF, DEPT PHYSIOL, CARDIFF CF1 1SS, WALES

[2] EOTVOS LORAND UNIV, DEPT COMPARAT PHYSIOL, BUDAPEST, HUNGARY

来源：

NEUROSCIENCE LETTERS | 1994年 / 172卷 / 1-2期

基金：

英国惠康基金;

关键词：

SLEEP; THALAMUS; GABA(B) RECEPTOR; OSCILLATION; EEG;

D O I：

10.1016/0304-3940(94)90685-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The gamma-aminobutyric acid (GABA)(B) receptor antagonists 2-OH-saclofen and CGP 35348 were injected in the thalamus of freely moving cats via a microdialysis probe while recording the sleep-waking cycle. The results obtained with the two antagonists were similar: wakefulness and the total sleep time were not affected by the blockade of GABA(B) receptors, but deep slow wave sleep and the mean power of slow waves (<10 Hz) were decreased, while light slow wave sleep was increased. These data suggest an involvement of thalamic GABA(B) receptors in the regulation of EEG slow waves.

引用

页码：155 / 158

页数：4

共 17 条

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