PHENOLIC CONSTITUENTS OF SELAGINELLA-DOEDERLEINII

被引:100
作者
LIN, RC
SKALTSOUNIS, AL
SEGUIN, E
TILLEQUIN, F
KOCH, M
机构
[1] UNIV PARIS 05, FAC PHARM, CNRS, URA 1310, PHARMACOGNOSIE LAB, F-75006 PARIS, FRANCE
[2] UNIV DIJON, FAC PHARM, PHARMACOGNOSIE LAB, F-21033 DIJON, FRANCE
关键词
SELAGINELLA DOEDERLEINII; SELAGINELLACEAE; PTERIDOPHYTA; PHENYLPROPANONES; LIGNANS; BIFLAVONOIDS; CYTOTOXIC ACTIVITY; CHINESE TRADITIONAL MEDICINE;
D O I
10.1055/s-2006-959443
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Eleven phenolic compounds have been isolated from the ethanolic extract of Selaginella doederleinii by a combination of chromatographic techniques. These are five lignans: (-)-lirioresinol A, (-)-lirioresinol B, (+)-wikstromol, (-)-nortracheloside, (+)-matairesinol (1), two phenylpropanones: 3-hydroxy-1(3 -methoxy-4-hydroxyphenyl)-propan-1-one (2), 3-hydroxy-1-(3,5-dimethoxy-4-hydroxyphenyl)-propan-1-one (3), and four biflavonoids: amentoflavone, 7,7''-di-O-methylamentoflavone, 7,4',7'',4'''-tetra-O-methylamentoflavone, and heveaflavone (4). Compounds 1, 2, and 3 are novel natural secondary metabolites. Their structures were deduced from their spectral data (mainly H-1-NMR, mass, and CD). Lignans are described here for the first time in the family Selaginellaceae. Their cytotoxic activity against L 929 murine cells accounts for the use of the plant in traditional Chinese medicine as an anticancer agent.
引用
收藏
页码:168 / 170
页数:3
相关论文
共 22 条
[1]   CONSTITUENTS OF WEST-AFRICAN MEDICINAL-PLANTS .12. LIGNANS AND OTHER CONSTITUENTS FROM CARISSA-EDULIS [J].
ACHENBACH, H ;
WAIBEL, R ;
ADDAEMENSAH, I .
PHYTOCHEMISTRY, 1983, 22 (03) :749-753
[2]   OCCURRENCE OF MATAIRESINOL IN MOUNTAIN HEMLOCK (TSUGA MERTENSIANA), WESTERN HEMLOCK (TSUGA HETEROPHYLLA), AND BALSAM (ABIES AMABILIS) [J].
BARTON, GM ;
GARDNER, JAF .
JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (01) :322-&
[3]  
Boughandjioua Nadia, 1992, Canadian Journal of Chemistry, V70, P1956, DOI 10.1139/v92-245
[4]  
CHATTERJEE A, 1984, P INDIAN AS-CHEM SCI, V93, P1031
[5]   DIE LIGNANE DES FICHTENHOLZES [J].
FREUDENBERG, K ;
KNOF, L .
CHEMISCHE BERICHTE-RECUEIL, 1957, 90 (12) :2857-2869
[6]  
Geiger H., 1988, FLAVONOIDS ADV RES 1, P99
[7]  
Geiger H., 1982, FLAVONOIDS ADV RES, P505
[8]  
Geiger H., 1975, FLAVONOIDS, P692
[9]   The constituents of natural phenolic resins - Part XVII A synthesis of l-matairesinol [J].
Haworth, RD ;
Slinger, FH .
JOURNAL OF THE CHEMICAL SOCIETY, 1940, :1098-1101
[10]  
INAGAKI I, 1972, CHEM PHARM BULL, V20, P2710