D-DIMER CONCENTRATIONS DURING NORMAL-PREGNANCY, AS MEASURED BY ELISA

被引：75

作者：

FRANCALANCI, I ^{[1
]}

COMEGLIO, P ^{[1
]}

LIOTTA, AA ^{[1
]}

CELLAI, AP ^{[1
]}

FEDI, S ^{[1
]}

PARRETTI, E ^{[1
]}

MELLO, G ^{[1
]}

PRISCO, D ^{[1
]}

ABBATE, R ^{[1
]}

机构：

[1] UNIV FLORENCE,CLIN OSTET GINECOL 2,FLORENCE,ITALY

来源：

THROMBOSIS RESEARCH | 1995年 / 78卷 / 05期

关键词：

D-DIMER; FIBRINOGEN; PREGNANCY;

D O I：

10.1016/0049-3848(95)00073-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In pregnant women a number of changes in blood clotting and fibrinolysis proteins have been reported so indicating the existence of a state of hypercoagulability. In addition to fibrinogen and antithrombin III (AT), D-dimer is frequently checked during pregnancy, in particular during at risk pregnancy, but the exact pattern of D-dimer modifications during uncomplicated pregnancy is not definitively described. The aim of this study was to establish the range values in three different periods of uncomplicated pregnancy (A: 1-20 wks; B: 21-30 wks; C: 31-40 wks). We measured plasma levels of D-dimer, clottable fibrinogen and AT in 108 consecutive normal pregnant women aged 16 to 42 years. In period A, the range of D-dimer values was 43-211 ng/mL, not different from controls, while fibrinogen levels were significantly higher (p<0.05) than in matched non pregnant women. Mean D-dimer levels were higher in periods B (p<0.05) and C (p<0.05) vs period A. Similarly, mean fibrinogen levels were found more elevated in periods B and C vs period A (p<0.05). A significant correlation was found between fibrinogen and D-dimer levels (p<0.001). No differences in AT levels were found among the three periods of pregnancy. The results of this study indicate that levels of D-dimer up to 685 mu g/L may be reached at the end of physiological pregnancy. This fact should be taken into account in the evaluation of hemostatic studies performed in uncomplicated and complicated pregnant women.

引用

页码：399 / 405

页数：7

共 18 条

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