THEORETICAL MODEL-BASED EQUATIONS FOR LINEAR FREE-ENERGY RELATIONSHIPS OF BIOLOGICAL-ACTIVITY OF IONIZABLE SUBSTANCES .1. EQUILIBRIUM-CONTROLLED POTENCY

被引:33
作者
MARTIN, YC [1 ]
HACKBARTH, JJ [1 ]
机构
[1] ABBOTT LABS,DEPT DRUG METAB,N CHICAGO,IL 60064
关键词
D O I
10.1021/jm00230a012
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
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页码:1033 / 1039
页数:7
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共 21 条
[1]   THE PARTITION OF ORGANIC COMPOUNDS BETWEEN HIGHER ALCOHOLS AND WATER [J].
COLLANDER, R .
ACTA CHEMICA SCANDINAVICA, 1951, 5 (05) :774-780
[2]   THE EFFECT OF PH UPON THE BACTERIOSTATIC ACTIVITY OF CERTAIN NITROPHENOLS [J].
COWLES, PB ;
KLOTZ, IM .
JOURNAL OF BACTERIOLOGY, 1948, 56 (03) :277-282
[3]   GENERAL INFLUENCE OF PHYSICOCHEMICAL PROPERTIES ON DRUG-RECEPTOR COMBINATION [J].
FLYNN, GL ;
YALKOWSKY, SH ;
WEINER, ND .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1974, 63 (02) :300-304
[4]   CORRELATION AND PREDICTION OF MASS-TRANSPORT ACROSS MEMBRANES .1. INFLUENCE OF ALKYL CHAIN-LENGTH ON FLUX-DETERMINING PROPERTIES OF BARRIER AND DIFFUSANT [J].
FLYNN, GL ;
YALKOWSKY, SH .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (06) :838-+
[6]   ANALYSIS OF STRUCTURE-ACTIVITY RELATIONSHIP OF SULFONAMIDE DRUGS USING SUBSTITUENT CONSTANTS [J].
FUJITA, T ;
HANSCH, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :991-&
[7]   NEW SUBSTITUENT CONSTANT PI DERIVED FROM PARTITION COEFFICIENTS [J].
FUJITA, T ;
HANSCH, C ;
IWASA, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (23) :5175-&
[8]   KINETICS AND MECHANISMS OF ACTION OF DRUGS ON MICROORGANISMS .8. QUANTIFICATION AND PREDICTION OF BIOLOGICAL ACTIVITIES OF META- AND PARA-SUBSTITUTED N1-PHENYLSULFANILAMIDES BY MICROBIAL KINETICS [J].
GARRETT, ER ;
MIELCK, JB ;
SEYDEL, JK ;
KESSLER, HJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :740-&
[9]   LIPOPHILIC CHARACTER AND BIOLOGICAL-ACTIVITY OF DRUGS .2. PARABOLIC CASE [J].
HANSCH, C ;
CLAYTON, JM .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1973, 62 (01) :1-21
[10]  
HANSCH C, 1973, STRUCTURE ACTIVITY R, V1, P75