HIGH-RESOLUTION AND TANDEM FOURIER-TRANSFORM MASS-SPECTROMETRY WITH CF-252 PLASMA DESORPTION

被引:20
作者
WILLIAMS, ER [1 ]
MCLAFFERTY, FW [1 ]
机构
[1] CORNELL UNIV,BAKER LAB,DEPT CHEM,ITHACA,NY 14853
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1016/1044-0305(90)85025-H
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
For ions formed by plasma desorption (PD) in a Fourier-transform mass spectrometer, high resolution measurements are demonstrated, such as 65,000 (FWHH) for the protonated molecularion of gramicidin S (MW 1140.7). Resolution is substantially improved by delaying measurements until a significant ion concentration has built up in the cell, and by collisionally deactivating the orbital kinetic energy of the ions. This also makes the ions available for subsequent dissociation steps, so that tandem mass spectrometry can be demonstrated for PD ions. With this for larger ions, collisionally activated dissociation (CAD) is effected with > 85% efficiency. The CAD spectra of (M + Na)+ and of fragment ions from the PD of gramicidin S provide structurally useful information. © 1990 American Society for Mass Spectrometry.
引用
收藏
页码:427 / 430
页数:4
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