NEUROLEPTIC-INDUCED CATALEPSY AS A MODEL OF PARKINSONS-DISEASE .1. EFFECT OF DOPAMINERGIC AGENTS

被引:24
作者
ELLIOTT, PJ
CLOSE, SP
WALSH, DM
HAYES, AG
MARRIOTT, AS
机构
[1] Neuropharmacology Department, Glaxo Group Research Ltd., Ware, SG12ODP, Hertfordshire
关键词
amphetamine; apomorphine; Catalepsy; fluphenazine; L-DOPA; Parkinson's disease; quinpirole; SKF; 38393; striatum; sulpiride;
D O I
10.1007/BF02260896
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Catalepsy was observed in the rat following intrastriatal injections of the dopamine antagonists sulpiride or fluphenazine and after subcutaneous administration of fluphenazine. The neuroleptic-induced catalepsy was reversed by the classical anti-parkinsonian agent L-DOPA and by agents that function through dopamine systems such as d- and methamphetamine and the direct D2 receptor agonist quinpirole. The D1 agonist SKF 38393, and the D1/D2 agonist apomorphine, were ineffective in this model. These results support limited use of the rat catalepsy model for the screening of potential anti-parkinsonian compounds and indicate that this procedure can provide valuable information concerning striatal dopamine function. © 1990 Springer-Verlag.
引用
收藏
页码:79 / 89
页数:11
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