PREPARATION, ISOLATION AND X-RAY CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF A STABLE, CRYSTALLINE CARBONIC ANHYDRIDE OF AN N-PROTECTED ALPHA-AMINO-ACID

被引：22

作者：

CHAN, CO ^{[1
]}

COOKSEY, CJ ^{[1
]}

CRICH, D ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT CHEM,LONDON WC1H 0AJ,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 07期

关键词：

D O I：

10.1039/p19920000777

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of methyl (2S,3aR,8aS)-2-carboxy-8-phenylsulfonyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole-1-carboxylate and isobutyl chloroformate in tetrahydrofuran at -15-degrees-C in the presence of trimethylamine results in the formation of the corresponding mixed carboxylic-carbonic anhydride. This unusually stable mixed anhydride was isolated in the form of an analytically pure crystalline solid and its structure verified crystallographically.

引用

页码：777 / 780

页数：4

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