A CD4-DERIVED PEPTIDE CARRIER BLOCKS ACUTE HIV-1 INFECTION INVITRO AND BINDS TO GP120 IN THE PRESENCE OF WALTER-REED STAGE 1-6 HIV+ SERA

被引：2

作者：

GHETIE, V ^{[1
]}

WHEELER, T ^{[1
]}

SCOTT, D ^{[1
]}

UHR, JW ^{[1
]}

VITETTA, ES ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,CTR CANC IMMUNOBIOL,DALLAS,TX 75235

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1992年 / 8卷 / 11期

关键词：

D O I：

10.1089/aid.1992.8.1945

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A peptide containing amino acid residues 41-84 of the CD4 molecule was synthetized and coupled through a thioether bond to human serum albumin. This conjugate bound to gp120 with an affinity that was half that of CD4 and blocked the HIV infection in vitro with an efficacy tenfold lower than that of CD4. More importantly, the CD4 peptide-human serum albumin conjugate could bind to gp120 in the presence of HIV' sera from 18 Walter Reed stage 1-6 patients.

引用

页码：1945 / 1948

页数：4

共 14 条

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