DIARRHEA AMONG AFRICAN CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-1-INFECTED MOTHERS - CLINICAL, MICROBIOLOGIC AND EPIDEMIOLOGIC FEATURES

被引:45
作者
PAVIA, AT
LONG, EG
RYDER, RW
NSA, W
PUHR, ND
WELLS, JG
MARTIN, P
TAUXE, RV
GRIFFIN, PM
机构
[1] CTR DIS CONTROL,NATL CTR INFECT DIS,INT AIDS PROGRAM,ATLANTA,GA 30333
[2] UNIV UTAH,DIV INFECT DIS,SALT LAKE CITY,UT 84112
[3] UNIV UTAH,DIV PEDIAT INFECT DIS,SALT LAKE CITY,UT 84112
[4] EMORY UNIV,SCH MED,DIV INFECT DIS,ATLANTA,GA 30322
[5] CTR DIS CONTROL,NATL CTR INFECT DIS,ENTER DIS BRANCH,ATLANTA,GA 30333
[6] CTR DIS CONTROL,NATL CTR INFECT DIS,PARASIT DIS BRANCH,ATLANTA,GA 30333
关键词
ACQUIRED IMMUNODEFICIENCY SYNDROME; HUMAN IMMUNODEFICIENCY VIRUS; PERINATAL TRANSMISSION; DIARRHEA EPIDEMIOLOGY; INFANTS;
D O I
10.1097/00006454-199211120-00002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Diarrhea and weight loss are common features of pediatric and adult human immunodeficiency type 1 (HIV-1) infection, particularly in developing countries. We studied prospectively episodes of diarrhea in 559 children, ages 10 to 15 months, participating in a longitudinal study of perinatal HIV-1 infection in Kinshasa, Zaire. Children with HIV-1 infection had more frequent episodes of diarrhea and were more likely to present with fever or moderate or severe dehydration and to have persistent or fatal diarrhea. Of 9 HIV- 1-positive infants with diarrhea, 3 had enteroadherence factor-positive Escherichia coli, compared with 5 of 74 HIV-1-negative children with diarrhea (P = 0.04); no other pathogen was associated with HIV-1 infection. In a logistic regression model diarrhea was significantly associated with HIV-1 infection in the child, moderate or severe malnutrition and symptoms of acquired immunodeficiency syndrome in the mother. Diarhea among children with perinatal HIV infection in Zaire is more severe than among uninfected children and is associated with malnutrition and advanced disease in the mother.
引用
收藏
页码:996 / 1003
页数:8
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