HIGHLY DIASTEREOSELECTIVE [2+2] CYCLOADDITIONS VIA CHELATION CONTROL - ASYMMETRIC-SYNTHESIS OF BETA-LACTONES

被引：28

作者：

ZEMRIBO, R ^{[1
]}

ROMO, D ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 24期

关键词：

D O I：

10.1016/0040-4039(95)00716-P

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chelation controlled [2+2] cycloadditions of trimethylsilylketene to chiral alpha- and beta-benzyloxyaldehydes followed by desilylation provides a highly diastereoselective route to functionalized beta-lactones. Several Lewis acids were examined and MgBr2 . Et(2)O was found to give the highest diastereoselectivities and yields.

引用

页码：4159 / 4162

页数：4

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