A SINGLE DOSE OF THE TOPICAL CARBONIC-ANHYDRASE INHIBITOR MK-927 DECREASES IOP IN PATIENTS

被引:23
作者
PFEIFFER, N
HENNEKES, R
LIPPA, EA
GREHN, F
GARUS, H
BRUNNERFERBER, FL
机构
[1] FREE UNIV BERLIN,AUGENKLIN,W-1000 BERLIN 33,GERMANY
[2] MERCK SHARP & DOHME LTD,W POINT,PA 19486
关键词
D O I
10.1136/bjo.74.7.405
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Inhibitor (CAI). We present the first singledose clinical trial of MK-927 in 24 patients with bilateral primary open-angle glaucoma or ocular hypertension. This investigation was conducted as a two-centre, double-masked, randomised, placebo controlled study. Patients received one drop of 2% MK-927 in one eye and placebo in the other eye. Modified diurnal intraocular pressure (IOP) curves were performed before the study and on one treatment day. A single dose of 2% MK-927 induced a peak mean IOP decrease of 10.5 mmHg at 4.5 hours postdose. With compensation for diurnal variation, as determined by the prestudy diurnal pressure curve, the net peak mean reduction of IOP caused by MK-927 was 7.5 mmHg versus a corresponding net change of 1.4 mmHg in the contralateral placebo treated eye. Thus a single dose of MK-927 gave a clinically significant IOP reduction in patients.
引用
收藏
页码:405 / 408
页数:4
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