FREE-RADICAL ACTIVITY IN TYPE-2 DIABETES

被引：159

作者：

COLLIER, A

WILSON, R

BRADLEY, H

THOMSON, JA

SMALL, M

机构：

[1] Diabetic Clinic, Gartnavel General Hospital, Glasgow

[2] University Department of Medicine, Royal Infirmary, Glasgow

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 01期

关键词：

Caeruloplasmin; Free radicals; Superoxide dismutase; Thiol groups; Type; 2; diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01302.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Free radical activity has been implicated in the development of diabetic vascular complications in Type 1 diabetes. The aim of the present study was to investigate the levels of free radical scavengers, particularly erythrocyte superoxide dismutase, plasma and erythrocyte lysate thiol, and caeruloplasmin in 22 Type 2 diabetic patients clinically free of complications, and 15 comparable non‐diabetic control subjects. The concentration (median (range)) of both superoxide dismutase (23 (10–39) vs 45 (25–75) μmol I−1; p < 0.001) and plasma thiol (374 (172–523) vs 460 (386–595) μmol I−1; p < 0.01) were reduced in the diabetic group. There were no significant differences in the concentration of erythrocyte lysate thiol (199 (114–520) vs 188 (114–328) μmol I−1) or plasma caeruloplasmin (18 (9–31) vs 24 (6–50) μmol I−1) between the groups. This reduction in superoxide dismutase and the imbalance in the redox status of the plasma and lysate thiol demonstrated is consistent with an increase in free radical activity in Type 2 diabetes. 1990 Diabetes UK

引用

页码：27 / 30

页数：4

共 23 条

[1] Fridovich I., The biology of oxygen radicals, Science, 201, pp. 875-880, (1978)
[2] Dormandy TL, An approach to free radicals, Lancet, 2, pp. 1010-1014, (1983)
[3] McCord JM, Oxygen‐derived free radicals in post‐ischaemic tissue injury, N Engl J Med, 312, pp. 159-163, (1985)
[4] Szamosi T., Gara I., Vereki I., Javor A., Ceskel R., Knoll J., Serum lipids, lipid peroxides and the care of children with high risk atherosclerotic family history, Atherosclerosis, 68, pp. 111-115, (1987)
[5] Stringer MD, Gorog PG, Freeman A., Kakkar VV, Lipid peroxides and atherosclerosis, Br Med J, 298, pp. 281-284, (1989)
[6] Jennings PE, Jones AF, Flowkowski CM, Lunec C., Barnett AH, Increased diene conjugates in diabetic subjects with microangiopathy, Diabetic Med, 4, pp. 452-456, (1987)
[7] Misra HP, Fridovich I., Superoxide dismutase, a photo‐chemical augmentation assay, Arch Biochem Biophys, 181, pp. 308-312, (1977)
[8] Gutteridge JMC, Superoxide dismutase and free radicals in clinical chemistry, Ann Clin Biochem, 13, pp. 393-398, (1976)
[9] Banford JC, Brown DM, McNeil CJ, Smith WC, Differences in the reaction of D‐penicillamine and 1‐cysteine with 5,5 dithiobis (2‐nitrobenzoic acid): a model for some in vivo differences, Inorganica Chimica Acta, 66, pp. 21-22, (1982)
[10] Banford JC, Brown DM, Hazelton RA, McNeil CJ, Smith WE, Sturrock RD, Altered thiol status in patients with rheumatoid arthritis, Rheumatol Int, 2, pp. 107-111, (1982)

← 1 2 3 →