ANGULAR HYDROXYMETHYLATION OF FUNCTIONALIZED DECALIN SYSTEMS

被引：19

作者：

CHAN, TH

SCHWERDTFEGER, AE

机构：

[1] Department of Chemistry, McGill University, Montreal, Quebec

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 10期

关键词：

D O I：

10.1021/jo00010a023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized beta-dicarbonyl bicyclic compounds 5 and 17 were hydroxymethylated at the angular position as the (benzyloxy)methoxy derivatives with diisopropylethylamine (DIPEA) and benzyl chloromethyl ether in the presence of paraformaldehyde. The stereochemistry of cis-8a-[[(benzyloxy)methoxy]methyl]-3-(phenylthio)-4a,5,6,8a-tetrahydronaphthalene-1,8(4H,7H)-dione (12) was confirmed by X-ray analysis of the ethylene ketal 16.

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页码：3294 / 3298

页数：5

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