SYNTHESIS OF ALPHA-VINYLIDENE-BETA-LACTAMS BY THE PALLADIUM-CATALYZED CARBONYLATION OF 4-AMINO-2-ALKYNYL CARBONATES

被引：30

作者：

MANDAI, T

RYODEN, K

KAWADA, M

TSUJI, J

机构：

[1] Department of Applied Chemistry, Faculty of Engineering, Okayama University of Science, 700, Ridai-cho, Okayama Japan

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 52期

关键词：

4-ETHYL-2,6,7-TRIOXO-1-PHOSPHABICYCLO [2.2.2]OCTANE; ALPHA-VINYLIDENE-BETA-LACTAMS; PALLADIUM-CATALYZED CARBONYLATION OF 4-AMINO-2-ALKYNYL CARBONATES;

D O I：

10.1016/0040-4039(91)80564-M

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catallyzed carbonylation of 4-amino-2-alkynyl carbonates proceeded under mild conditions to afford alpha-vinylidene-beta-lactams in moderate yields. The cyclic phosphite, 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane was found to be the best ligand.

引用

页码：7683 / 7686

页数：4

共 7 条

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