IMPROVEMENT OF MOTOR-PERFORMANCE OF HIV-POSITIVE PATIENTS UNDER AZT THERAPY

被引：35

作者：

ARENDT, G ^{[1
]}

HEFTER, H ^{[1
]}

BUESCHER, L ^{[1
]}

HILPERATH, F ^{[1
]}

ELSING, C ^{[1
]}

FREUND, HJ ^{[1
]}

机构：

[1] UNIV DUSSELDORF,DEPT MED,W-4000 DUSSELDORF 1,GERMANY

来源：

NEUROLOGY | 1992年 / 42卷 / 04期

关键词：

D O I：

10.1212/WNL.42.4.891

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We performed motor tests (most rapid alternating movements [MRAMs] of index fingers and most rapid contractions [MRCs] of voluntary isometric index finger extensions) in HIV-positive patients with (group 1) and without (group 2) AZT treatment over a 6-month period. Whereas MRAMs remained uninfluenced, MRCs showed a clear improvement in the treated group and a decline in the nontreated group, according to the T helper cell counts. MRCs were not only a sensitive test procedure for detecting subclinical lesions in HIV-positive patients, but also a reliable therapy control measurement.

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页码：891 / 896

页数：6

相关论文

共 14 条

[1] MOTOR DYSFUNCTION IN HIV-INFECTED PATIENTS WITHOUT CLINICALLY DETECTABLE CENTRAL-NERVOUS DEFICIT [J].

ARENDT, G ;

HEFTER, H ;

ELSING, C ;

STROHMEYER, G ;

FREUND, HJ .

JOURNAL OF NEUROLOGY, 1990, 237 (06) :362-368

[2] REACTION-TIME IN PARKINSONS-DISEASE [J].

EVARTS, EV ;

TERAVAINEN, H ;

CALNE, DB .

BRAIN, 1981, 104 (MAR) :167-186

[3] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[4]

FURMAN PA, 1988, AM J MED, V85, P176

[5] IMPAIRMENT OF RAPID MOVEMENT IN HUNTINGTONS-DISEASE [J].

HEFTER, H ;

HOMBERG, V ;

LANGE, HW ;

FREUND, HJ .

BRAIN, 1987, 110 :585-612

[6]

HEFTER H, 1991, THESIS U DUESSELDORF

[7] PLASMA AND CEREBROSPINAL-FLUID PHARMACOKINETICS OF 3'-AZIDO-3'-DEOXYTHYMIDINE - A NOVEL PYRIMIDINE ANALOG WITH POTENTIAL APPLICATION FOR THE TREATMENT OF PATIENTS WITH AIDS AND RELATED DISEASES [J].

KLECKER, RW ;

COLLINS, JM ;

YARCHOAN, R ;

THOMAS, R ;

JENKINS, JF ;

BRODER, S ;

MYERS, CE .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (04) :407-412

[8] HIV WITH REDUCED SENSITIVITY TO ZIDOVUDINE (AZT) ISOLATED DURING PROLONGED THERAPY [J].

LARDER, BA ;

DARBY, G ;

RICHMAN, DD .

SCIENCE, 1989, 243 (4899) :1731-1734

[9] ZIDOVUDINE IN AIDS DEMENTIA COMPLEX [J].

MORRISS, R ;

HOUSE, A .

BRITISH MEDICAL JOURNAL, 1989, 299 (6709) :1218-1218

[10] INDUCTION OF ENDOGENOUS VIRUS AND OF THYMIDINE KINASE BY BROMODEOXYURIDINE IN CELL-CULTURES TRANSFORMED BY FRIEND VIRUS [J].

OSTERTAG, W ;

ROESLER, G ;

KRIEG, CJ ;

KIND, J ;

COLE, T ;

CROZIER, T ;

GAEDICKE, G ;

STEINHEIDER, G ;

KLUGE, N ;

DUBE, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (12) :4980-4985