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DNA RECOGNITION AND SUPERSTRUCTURE FORMATION BY HELIX-TURN-HELIX PROTEINS
被引：49
作者：
SUZUKI, M
YAGI, N
GERSTEIN, M
机构：
[1] TOHOKU UNIV,SCH MED,SENDAI,MIYAGI 98077,JAPAN
[2] STANFORD UNIV,DEPT BIOL STRUCT,STANFORD,CA 94305
来源：
PROTEIN ENGINEERING
|
1995年
/
8卷
/
04期
关键词：
CAP;
DNA BENDING;
FIS;
HELIX-TURN-HELIX;
NMR;
TRANSCRIPTION FACTOR;
D O I：
10.1093/protein/8.4.329
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
The way helix-turn-helix proteins recognize DNA is analysed by comparing their sequences, structures, and binding specificities. Individual recognition helices in these proteins bind to four DNA base pairs with the same geometry. However, pairs of recognition helices in the protein dimers can have different separations and orientations, These differences are used for discriminating between DNAs which have different superstructures, in particular, different numbers of base pairs between sets of the four base pairs.
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页码：329 / 338
页数：10
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